杩???锛?娴?姹?澶у????╃郴缁?宸ョ?涓?椋???绉?瀛﹀??㈢?瀹???琛ㄤ?涓?椤圭??绌讹?杩?椤圭??绌跺?╃??KB椤圭?????版???浼颁????惰??????娑?璐逛??ㄥ?????瑰?????姝讳骸?????崇郴??缁???琛ㄦ??锛??ㄤ腑?界?甯搁??ㄨ???惰????涓??鸿??т腑椋???椋?绠$?????撮?姝讳骸椋??╃?稿?炽??
1.??绌惰???
姝ゅ??锛?涓?椤圭撼??959渚???涓?????涓??界旱???ュ悍?垮?璋??ユ?剧ず锛??跺???姣?澶╂???ョ?????惰????涓?楂?榫???骞翠汉锛???0宀?锛??ㄥ??姝讳骸??楂?10%??姝g?稿?炽??姝ゅ?锛???椤归??瀵圭??????????????绌惰〃??锛?椋??ㄨ???惰????涓?缁??磋???????虹?????剧????姝g?稿?炽???╂??璇???〃??锛?椋??ㄧ?????惰????涓????跨?ゆ?浜$????姝g?稿?炽???惰??锛?灏???????绌惰?浼拌???惰????娑?璐逛?蹇?琛?绠$?剧??锛?CVD锛?????????姝讳骸??涔??村?宠????
2.??绌惰?绋?
??涓??芥?㈡?х?????绘?х??绌垛??椤圭? China Kadoorie Biobank (CKB)? 2002 骞寸?卞?????ㄦ?瑰??绔?椤癸??扮?变腑?藉?诲?绉?瀛﹂?€????浜?ぇ瀛﹀???卞?界??娲ュぇ瀛﹁????寮?灞???涓?椤瑰ぇ???㈡?х???介????浣???绌堕」????娴?姹?澶у???绌跺?㈤????绌跺?╃??KB椤圭?????版???浼颁????惰??????娑?璐逛??ㄥ?????瑰?????姝讳骸?????崇郴????004骞?????008骞??????达?姣?涓??板??00-150涓???垮??浣???????30-79宀???灞?姘??借???璇峰??????绌讹???缁??ㄨ?峰?涔﹂?㈢?ユ???????????典?锛?????浜?512,900浜恒??姣?浣?绗﹀???′欢????涓????藉~??浜?涓?浠界?辫?璋???绠$????绗?璁版???佃??渚挎?哄?璋??ラ???凤????????汉?g?璁″??瑰???楗????琛?涓虹??娲绘?瑰???绱?锛?濡?楗??????哥????浣??叉椿?ㄣ??瀹跺涵瀹ゅ??绌烘?姹℃???????插??褰????ㄨ?????$????绮剧??舵??锛?浣跨?ㄧ患???介??璇????璋???〃锛??????插?诧???瀵瑰コ?э???浣?妫????点????缁?锛????や?浜???绱???锛???绌跺?㈤??瀵逛腑??40,415????涓昏??㈡?х?剧????30~79宀?????涓???骞冲????璁?0骞达??卞????28,625渚?姝讳骸??
3.??绌剁???
??绌舵?版??〃??椋??ㄨ???惰????涓?杈?楂???蹇?琛?绠$?剧??锛?CVD锛?姝讳骸???稿?筹?浣?涓??荤????姝讳骸?????绘?浜$??涓??稿?筹??蜂???瑷?锛?椋??ㄨ???惰????涓??鸿??т腑椋???姝讳骸??杈?楂??稿?筹?涓???娑?璐硅???告?锛?姣??ㄩ??ㄨ???惰????1-3澶╀汉缇ょ???鸿??т腑椋?姝讳骸椋??╅?32%锛?缁?甯告?璐硅??锛???澶????椋??╅?15%锛?姝ゅ?锛?缁?甯搁??ㄨ???惰????涓?娑?????????姝讳骸????椋?绠$??姝讳骸????椋??╁???????13%??45%???炽?? ?讳?锛?缁???琛ㄦ??锛?缁?甯搁??ㄨ???惰????涓??鸿??т腑椋???椋?绠$?????撮?姝讳骸椋??╃?稿?炽???哄?朵?锛?????涓???????杩?楂????芥???浜¢??╁?????涓昏?????锛???????涓???N-浜?纭??哄?????╄?璁や负???杩?椋?绠$?????????遍?╁??绱????煎?娉ㄦ??????锛?杩?椋??ㄩ??娴告场?跺???ㄥ??ㄤ腑???佃?冲?2?ㄧ?????惰????锛?涓?椋?????椋??╂???炽??杩??朵腑???稿?虫?у樊寮????芥???变?涓????????舵?规???浣跨?ㄤ???浠ュ???璋??冲??